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Dipeptidase 3

Molecular classification: Enzyme, Membrane-bound glycoprotein

Overview

Dipeptidase 3 (DPEP3) is a membrane-bound glycoprotein belonging to the dipeptidase family. While structurally similar to other dipeptidases, it exhibits significantly reduced or absent catalytic activity due to key amino acid substitutions in its active site. Its primary expression is in testicular tissue, suggesting a specialized role in male reproductive biology rather than general peptide hydrolysis. Although related to pathways like fatty acid metabolism and anti-inflammatory cytokine production, its direct involvement is unclear due to its low enzymatic activity.

Other names: MBD3

Biological functions

Peptide metabolism (putative)Testicular functionFertility system development

Disease associations

Cancer (Aberrant expression in tumors)

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