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Target intelligence / Profile preview
Dipeptidyl Peptidase 1 (DPPI)
- Target
- DPPI
- Molecular classification
- Enzyme, Lysosomal cysteine protease, Peptidase, Exopeptidase
01
Overview
Dipeptidyl peptidase 1 (DPPI), also known as cathepsin C, is a lysosomal cysteine protease that plays a key role in the activation of granule-associated serine proteases in immune and inflammatory cells. It catalyzes the removal of N-terminal dipeptides from polypeptides, leading to the maturation and activation of enzymes like granzymes and neutrophil serine proteases. DPPI deficiency is associated with impaired immune function and inflammatory disorders, making it a potential therapeutic target for modulating excessive neutrophil activity.
- Other names
- Cathepsin CDipeptidyl aminopeptidase IDipeptidyl transferaseDipeptide arylamidase IDAP I
02
Mechanism of action
Inhibition of DPPI to modulate neutrophil activity
03
Biological functions
Activation of granule-associated serine proteasesMaturation of granzymesMaturation of neutrophil serine proteasesImmune responseApoptosis induction
04
Disease associations
Papillon-Lefèvre syndromeHaim-Munk syndromeInflammationLung diseases
05
Safety considerations
Potential for broad immune suppression if not carefully modulatedTissue damage during chronic inflammation
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