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Target intelligence / Profile preview
Dipeptidyl Peptidase-4 (DPP-4)
- Target
- DPP-4
- Molecular classification
- Enzyme, Serine exopeptidase, Type II transmembrane glycoprotein
01
Overview
Dipeptidyl Peptidase-4 (DPP-4), also known as CD26, is a serine exopeptidase that cleaves dipeptides from the N-terminal end of polypeptides. It plays a crucial role in glucose metabolism by degrading incretin hormones like GLP-1 and GIP. DPP-4 is also involved in immune regulation and other physiological processes. It is a therapeutic target for type 2 diabetes, with DPP-4 inhibitors being used to enhance insulin secretion.
- Other names
- DPPIVCD26Adenosine deaminase complexing protein 2
02
Mechanism of action
DPP-4 inhibitors block the degradation of incretin hormones (GLP-1 and GIP), leading to increased insulin secretion and reduced glucagon secretion in a glucose-dependent manner.
03
Biological functions
Glucose metabolism regulationIncretin degradationImmune regulationT-cell activationSignal transductionEnergy metabolismModulation of inflammationApoptosisCell adhesion
04
Disease associations
Type 2 Diabetes MellitusLung diseasesCOVID-19 (possible disease progression marker)Tumor suppression/development (context dependent)
05
Interacting drugs
Sitagliptin
2 more in the full profile.
06
Biomarkers
Potential biomarker for certain lung diseasesPossible disease progression marker for COVID-19
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