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Target intelligence / Profile preview
Dipeptidyl Peptidase 7 (DPP7)
- Target
- DPP7
- Molecular classification
- Serine protease, Enzyme, S28 serine peptidases
01
Overview
Dipeptidyl Peptidase 7 (DPP7) is a serine protease that cleaves dipeptides from the N-terminus of polypeptides, specifically when the penultimate residue is proline. Primarily expressed in quiescent lymphocytes, it plays a critical role in suppressing apoptosis and maintaining cell survival. DPP7's involvement in glucose homeostasis also suggests potential links to metabolic disorders. It functions as a homodimer and is localized to intracellular vesicles, exhibiting enzymatic activity across a broad pH range.
- Other names
- DPPIIQPPDipeptidyl peptidase 2
02
Mechanism of action
Serine protease inhibitor
03
Biological functions
Enzymatic activityApoptosis regulationGlucose homeostasisPost-proline cleaving aminopeptidase activity
04
Disease associations
Immune regulationMetabolic diseases
05
Safety considerations
Apoptosis induction in quiescent lymphocytes
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