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Dipeptidyl Peptidase 8 (DPP8)
- Target
- DPP8
- Molecular classification
- Enzyme, Serine protease, Peptidase S9B
01
Overview
Dipeptidyl peptidase 8 (DPP8) is an intracellular serine protease that cleaves dipeptides from the N-terminus of polypeptides, specifically at proline or alanine residues. It belongs to the peptidase S9B family and shares structural and functional similarities with DPP4. DPP8 is ubiquitously expressed and plays roles in protein maturation, degradation, and immune regulation. Inhibition of DPP8, particularly in conjunction with its homolog DPP9, can activate inflammasomes and induce pyroptosis, highlighting potential therapeutic implications and safety concerns.
- Other names
- DP8DPRP1MSTP141MST097MSTP097MSTP135DPRP-1
02
Mechanism of action
Inhibition of DPP8 and DPP9 leads to inflammasome activation via NLRBP1/CARD8 pathways, resulting in pyroptosis.
03
Biological functions
Protein processingRegulation of immune responsePrevention of spontaneous pyroptosis
04
Disease associations
InflammationImmunological disorders
05
Safety considerations
Potential for adverse inflammatory responsesOff-target effects due to ubiquitous expressionInduction of pyroptosis
06
Interacting drugs
Val-boroPro
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