Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Dipeptidyl Peptidase 9 (DPP9)
- Target
- DPP9
- Molecular classification
- Enzyme, Serine protease, Exopeptidase
01
Overview
Dipeptidyl peptidase 9 (DPP9) is a serine protease enzyme that cleaves Xaa-Pro dipeptides from the N-termini of proteins. It plays a role in regulating immunity, energy metabolism, cell survival, proliferation, apoptosis, and adhesion/migration. Unlike DPP4, DPP9 is primarily located in the cytoplasm and nucleus. Altered DPP9 function is linked to type 2 diabetes, obesity, cancer, and immune disorders. It is a key inhibitor of caspase-1-dependent pyroptosis in monocytes/macrophages and interacts with inflammasome regulators like NLRP1 and CARD8. It also interacts with Filamin A and Syk kinase, modulating B-cell signaling.
- Other names
- DP9DPLP9DPRP-2DPRP2DPP IX
02
Mechanism of action
Inhibition of DPP9 to modulate pyroptosis and downstream signaling pathways.
03
Biological functions
Immune responseCell deathCell survivalCell proliferationEnergy metabolismApoptosisCell adhesionCell migrationRegulation of inflammasomes
04
Disease associations
Type 2 diabetesObesityCancerImmune regulation disorders
05
Safety considerations
Inhibition may accelerate tumor development/progression depending on context.Induction of pyroptosis in certain cell types (e.g., acute myeloid leukemia cells).
Beyond the preview
Go deeper on Dipeptidyl Peptidase 9 (DPP9).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Dipeptidyl Peptidase 9 (DPP9).