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Target intelligence / Profile preview
Dipeptidyl Peptidase-IV (DPP4)
- Target
- DPP4
- Molecular classification
- Serine exopeptidase, Type II transmembrane glycoprotein
01
Overview
Dipeptidyl Peptidase-IV (DPP4) is a serine exopeptidase that removes N-terminal dipeptides from polypeptides with proline or alanine in the penultimate position. It exists as a type II transmembrane glycoprotein and also in a soluble form. DPP4 plays crucial roles in glucose metabolism by degrading incretins, immune regulation through T-cell activation, and cell migration. It is a therapeutic target for type II diabetes, with DPP4 inhibitors (gliptins) used to improve glycemic control.
- Other names
- Dipeptidyl peptidase IVCD26Adenosine deaminase complexing protein 2 (ADCP2)T-cell activation antigen CD26
02
Mechanism of action
DPP4 inhibitors prolong incretin action to improve glycemic control by preventing the degradation of incretins like GLP-1 and GIP.
03
Biological functions
Enzymatic activityRegulation of glucose metabolismImmune regulationModulation of cell migration and proliferationViral entry co-receptor
04
Disease associations
Type II Diabetes MellitusCancerImmunology
05
Interacting drugs
Sitagliptin
1 more in the full profile.
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