Dipeptidyl peptidase-like protein 6 (DPP6)

Dipeptidyl peptidase-like protein 6 (DPP6) is a non-catalytic, transmembrane auxiliary subunit that associates with A-type Kv4 potassium channels in neurons[1][2]. DPP6 strongly influences channel gating, current amplitude, and membrane localization, helping regulate neuronal excitability, action potential backpropagation, and dendritic signaling[1][2][3]. Besides its ion channel modulatory role, DPP6 independently promotes filopodia growth and stability, playing a critical part in synaptic formation and maintenance. DPP6 is associated with several neurological disorders (ALS, dementia, intellectual disability, Tourette’s syndrome, microcephaly, autism spectrum disorder), highlighting its importance in CNS function and development[1]. While not an enzymatically active peptidase, DPP6’s structure is related to dipeptidyl peptidases, underlining its role as a specialized regulator of potassium channel activity and neuronal signaling[1][2][3].

Other names

A-type potassium channel modulatory protein DPP6Dipeptidyl aminopeptidase-like protein 6Dipeptidyl aminopeptidase-related proteinDipeptidyl peptidase VIDPP VIDPPXDPL1Dipeptidyl-peptidase 6VF2MRD33

Not applicable directly; as an auxiliary subunit, DPP6 modulates potassium channel function, influencing gating kinetics, channel localization, and neuronal excitability[1][2][3].