Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Diphtheria CRM197 Protein (CRM197)
- Target
- CRM197
- Molecular classification
- Toxin, Mutated Protein, Carrier Protein
01
Overview
CRM197 is a non-toxic mutant form of diphtheria toxin, characterized by a single amino acid substitution (G52E), that is widely used as a carrier protein in conjugate vaccines to enhance the immunogenicity of polysaccharides and haptens. It functions by providing T-cell epitopes and converting T-cell independent antigens into T-cell dependent antigens. Beyond vaccines, CRM197 has shown potential in cancer research by binding to heparin-binding EGF-like growth factor (HB-EGF), reducing angiogenesis, and initiating apoptosis.
- Other names
- CRM197Diphtheria Toxin Mutant CRM197
02
Mechanism of action
Acts as a carrier protein to enhance the immunogenicity of conjugated antigens. Binds to HB-EGF, reducing angiogenesis and initiating apoptosis in cancer cells.
03
Biological functions
Vaccine CarrierEnhances ImmunogenicityT-cell activationBinds to HB-EGF (Heparin-binding EGF-like growth factor)
04
Disease associations
Infectious Disease (as vaccine target)Cancer (potential therapeutic agent)
05
Safety considerations
Low-yield purificationRequires sophisticated culture conditions
06
Interacting drugs
Prevnar®
Beyond the preview
Go deeper on Diphtheria CRM197 Protein (CRM197).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Diphtheria CRM197 Protein (CRM197).