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Corynebacterium diphtheriae Toxin Protein (Diphtheria Toxin)
- Target
- Diphtheria Toxin
- Molecular classification
- Exotoxin, ADP-ribosylating bacterial toxin, Virulence factor
01
Overview
The diphtheria toxin is a potent exotoxin produced by Corynebacterium diphtheriae. It inhibits eukaryotic protein synthesis by ADP-ribosylating elongation factor 2 (eEF2). The toxin consists of two fragments: Fragment A, which possesses the catalytic activity, and Fragment B, which mediates binding to the host cell receptor (HB-EGF) and translocation of Fragment A into the cytosol.
- Other names
- Diphtheria ToxinDTtox protein
02
Mechanism of action
ADP-ribosylation of eukaryotic elongation factor 2 (eEF2), leading to inhibition of protein synthesis and cell death.
03
Biological functions
Inhibition of eukaryotic translationCell deathADP-ribosylation of eEF2
04
Disease associations
DiphtheriaInfection
05
Safety considerations
High toxicityPotential for off-target effects if used in targeted therapiesImmunogenicity
06
Interacting drugs
Diphtheria antitoxin
1 more in the full profile.
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