Target intelligence / Profile preview

Diphtheria Toxin A Chain (DtxA)

Target: DtxA
Molecular classification: Enzyme, ADP-ribosyltransferase, Toxin

Overview

The diphtheria toxin A chain is the N-terminal fragment of the diphtheria toxin, produced by *Corynebacterium diphtheriae*. It is an enzyme (ADP-ribosyltransferase) that inhibits protein synthesis in eukaryotic cells by ADP-ribosylating elongation factor 2 (eEF-2), leading to cell death. It is used as a protein delivery vehicle, but has safety concerns due to its high toxicity.

Mechanism of action

Catalyzes ADP-ribosylation of eukaryotic elongation factor 2 (eEF-2), inactivating it and halting protein synthesis.

Biological functions

Protein synthesis inhibitionCell deathADP-ribosylation

Disease associations

InfectionDiphtheria

Safety considerations

High toxicityPotential for off-target effects if used as a therapeutic delivery vehicle

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