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Target intelligence / Profile preview
Diphtheria Toxin CRM197 (CRM197)
- Target
- CRM197
- Molecular classification
- Toxin (Detoxified), Carrier Protein
01
Overview
CRM197 is a genetically detoxified mutant of diphtheria toxin used as a carrier protein in conjugate vaccines. The G52E mutation abolishes its ADP-ribosyltransferase activity, rendering it non-toxic while preserving its immunogenicity and ability to conjugate to polysaccharides and haptens. This makes it an effective tool for eliciting robust immune responses against bacterial pathogens, particularly in infants.
- Other names
- Diphtheria toxin variant CRM197 protein carrierCRM197Corynebacterium diphtheriae CRM197
02
Mechanism of action
Carrier protein facilitating T-cell dependent immune response to conjugated antigens.
03
Biological functions
Immunogenic carrierConjugation to polysaccharides/haptensEnhancing vaccine efficacy
04
Disease associations
Prevention of bacterial infections (Streptococcus pneumoniae, Haemophilus influenzae type b, Neisseria meningitidis)
05
Safety considerations
Potential residual toxicity in specific cell lines (in vitro)Carrier-induced immune suppression (less than tetanus toxoid)
06
Interacting drugs
Prevnar/Prevnar13 (Pneumococcal conjugate vaccine)
2 more in the full profile.
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