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Diphtheria toxin CRM197 protein carrier (None)

Target: None
Molecular classification: Protein Carrier, Toxin (mutated)

Overview

CRM197 is a genetically detoxified, non-toxic mutant of diphtheria toxin used as a carrier protein in conjugate vaccines to enhance the immunogenicity of polysaccharides and haptens. It is produced by a single amino acid substitution (G52E) that abolishes ADP-ribosyltransferase activity. It acts by converting T-cell independent antigens into T-cell dependent ones. CRM197 has a well-established safety profile and is included in several globally used pediatric vaccines.

Mechanism of action

Converts T-cell independent antigens into T-cell dependent ones, leading to robust antibody production.

Biological functions

Enhancing immunogenicity of antigensReceptor-mediated transcytosis

Disease associations

Infection (vaccine preventable diseases)

Safety considerations

Residual cytotoxicity under specific in vitro conditions

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