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Target intelligence / Profile preview
Diphtheria Toxin Cross-Reactive Material 197 (CRM197)
- Target
- CRM197
- Molecular classification
- Protein, Mutant Protein, Carrier Protein
01
Overview
CRM197 is a non-toxic mutant of the diphtheria toxin, widely used as a carrier protein in conjugate vaccines to enhance immunogenicity of polysaccharides and haptens. It is produced by a single amino acid substitution (Gly52→Glu), abolishing ADP-ribosylation activity and rendering it non-toxic, while retaining immunological identity to wild-type diphtheria toxin. Used in vaccines against pneumococcal, meningococcal, and Haemophilus influenzae type b diseases.
- Other names
- Cross-reactive material 197Non-toxic diphtheria toxin mutant
02
Mechanism of action
Acts as a carrier protein; conjugation converts immune response from T-cell independent to T-cell dependent.
03
Biological functions
Carrier for vaccine antigen conjugationEnhancement of immunogenicityT-cell dependent immune response induction
04
Disease associations
Prevention of bacterial diseases (Pneumococcal, Meningococcal, Haemophilus influenzae type b)
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