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Target intelligence / Profile preview
Diphtheria Toxin Protein Carrier (CRM197)
- Target
- CRM197
- Molecular classification
- Toxin (detoxified), Protein Carrier
01
Overview
CRM197 is a genetically detoxified, non-toxic mutant of diphtheria toxin used as a carrier protein in conjugate vaccines. It enhances the immunogenicity of polysaccharides and haptens, making them effective antigens for immune response. The G52E mutation abolishes ADP-ribosyltransferase activity while preserving immunogenicity.
- Other names
- Diphtheria ToxoidCRM197
02
Mechanism of action
Acts as a carrier protein to convert poorly immunogenic polysaccharide antigens into T-cell dependent antigens when covalently linked, enhancing antibody production.
03
Biological functions
Enhancing immunogenicity of antigensInducing antibody productionT-cell dependent antigen presentation
04
Disease associations
Prevention of DiphtheriaPrevention of Pneumococcal diseasePrevention of Haemophilus influenzae type b (Hib) diseasePrevention of Meningococcal disease
05
Safety considerations
Residual toxicity in some cell lines (not relevant in human vaccines)Potential for carrier-induced suppression
06
Interacting drugs
Pneumococcal conjugate vaccine (Prevnar®)
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