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Target intelligence / Profile preview
Diphtheria Toxoid Protein Carrier (DT)
- Target
- DT
- Molecular classification
- Detoxified Bacterial Exotoxin, Carrier Protein
01
Overview
The diphtheria toxoid protein carrier is a detoxified form of the diphtheria toxin, commonly used as a carrier protein in conjugate vaccines. It enhances the immunogenicity of polysaccharide antigens by converting them from T-cell independent to T-cell dependent antigens, thereby eliciting a stronger and longer-lasting immune response. Variants include formaldehyde-inactivated DT and the genetically modified nontoxic mutant CRM197.
- Other names
- Diphtheria ToxoidCRM197DT carrier protein
02
Mechanism of action
Conjugation to polysaccharide antigens to enhance immunogenicity
03
Biological functions
Enhances immunogenicity of polysaccharide antigensInduces T-cell dependent immune responseProvides T-helper cell epitopesSupports B-cell memory formation
04
Disease associations
Prevention of infectious diseases (*Streptococcus pneumoniae*, *Haemophilus influenzae* type b, *Neisseria meningitidis*)
05
Safety considerations
Carrier-induced suppression (lower risk for CRM197)Potential for allergic reactions (rare)
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