Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Diphtheria Toxoid Protein (DT)
- Target
- DT
- Molecular classification
- Toxoid, Vaccine Antigen, Modified Toxin
01
Overview
Diphtheria toxoid is an inactivated (detoxified) form of diphtheria toxin, used as a vaccine antigen to induce immunity against diphtheria. The native toxin is produced by Corynebacterium diphtheriae strains that are lysogenized by specific bacteriophages carrying the tox gene. The toxoid retains immunogenicity but lacks toxicity, making it suitable for safe use in vaccines. Immunization induces neutralizing antibodies that protect against disease caused by natural infection with C. diphtheriae producing active toxin proteins.
- Other names
- Diphtheria Toxin (inactivated)DT Toxoid
02
Mechanism of action
Induction of neutralizing antibodies against diphtheria toxin. The toxoid form prevents ADP-ribosylation of eEF-2 by eliciting an immune response that recognizes and neutralizes the active toxin.
03
Biological functions
Antigen presentationImmune response inductionVaccination
04
Disease associations
Prevention of DiphtheriaImmunization
05
Safety considerations
Local injection site reactions (pain, redness, swelling)FeverAllergic reactions (rare)Guillain-Barré Syndrome (very rare)
06
Interacting drugs
Vaccines containing Diphtheria Toxoid (e.g., DTaP, Tdap, DT, Td)
07
Biomarkers
Anti-Diphtheria Toxoid IgG antibody titerSeroconversion rate
Beyond the preview
Go deeper on Diphtheria Toxoid Protein (DT).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Diphtheria Toxoid Protein (DT).