Direct replacement of damaged cells

"Direct replacement of damaged cells" is a descriptive term for cell-based regenerative medicine strategies rather than a specific molecular target like a receptor or enzyme. This therapeutic modality involves the administration of live cells, such as stem cells or specialized progeny, to restore biological functions lost due to chronic disease or acute injury (NIH, 2023). In clinical practice, this is most commonly exemplified by hematopoietic stem cell transplants for blood disorders, but experimental applications include transplanting dopaminergic neurons for Parkinson's disease or beta cells for Type 1 diabetes (PubMed, 2022). Because this entry refers to a broad therapeutic approach and not a discrete molecule, it is classified as an incorrect target name for pharmacological screening. The success of such therapies relies on the successful engraftment, survival, and integration of the donor cells into the host's existing tissue architecture (StatPearls, 2023).

Other names

Cell therapyCell replacement therapyRegenerative medicineCell transplantationStem cell therapy

The transplantation of functional, healthy cells into a patient to replace or repair tissues that have been lost or damaged by disease or injury, thereby restoring physiological function.