Dirofilaria immitis (Adult Heartworms)

Dirofilaria immitis, commonly known as heartworm, is a parasitic nematode that resides in the pulmonary arteries and right ventricle of infected hosts, primarily dogs. The adult worms cause vascular damage, leading to pulmonary hypertension and congestive heart failure. Therapeutic strategies target different stages of the heartworm life cycle, focusing on preventing infection and eliminating adult worms. The ecdysone receptor pathway, dependent on Wolbachia symbiosis, represents a potential drug target. Understanding the molecular and cellular features of D. immitis is crucial for developing effective and safe treatments.

Other names

HeartwormAdult HeartwormsD. immitisDirofilaria

Heartworm preventatives: Interfere with nerve and muscle function of microfilariae and larvae. Adulticides: Arsenical compound that kills adult heartworms.