Disabled homolog 2 (DAB2)

Disabled homolog 2 (DAB2) is a cytosolic adaptor protein primarily known for its role as a clathrin-associated sorting protein (CLASP) essential for clathrin-mediated endocytosis of selected cargo proteins, including the LDL receptor, integrin β1, and others[2][3][4][5]. DAB2 contains an N-terminal phosphotyrosine-binding (PTB) domain that recognizes NPXY internalization motifs in receptor cargo, mediating the recruitment and assembly of clathrin-coated pits and vesicle trafficking. It interacts with multiple signaling molecules, including transforming growth factor-beta (TGF-β) receptors, Smad proteins, and components of the Wnt signaling pathway, and is involved in the regulation of cell adhesion, differentiation, and immune responses. DAB2 acts as a tumor suppressor, and its loss is correlated with various cancers, particularly ovarian carcinoma. Although no drugs target DAB2 directly, dysregulation of its expression or function impacts pathways relevant to cancer biology, lipid metabolism, and immune modulation[1][2][4][5][6].

Other names

DOC2DOC-2Differentially expressed in ovarian carcinoma 2Differentially-expressed protein 2Clathrin adaptor proteinDabMitogen-responsive phosphoproteinDAB adaptor protein 2Disabled (Drosophila) homolog 2Disabled homolog 2, mitogen-responsive phosphoprotein

Not directly targeted by drugs; molecular function primarily as an adaptor in endocytosis and signaling[4][5]