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DISC1 fusion partner 1 (DISC1FP1)
- Target
- DISC1FP1
- Molecular classification
- long noncoding RNA (lncRNA), fusion partner gene
01
Overview
DISC1 fusion partner 1 (DISC1FP1), also known as Boymaw, is a gene disrupted in chromosome 11 in the t(1;11) translocation associated with schizophrenia and major psychiatric disorders. Creation of fusion genes involving DISC1FP1 (e.g., DISC1-Boymaw) leads to inhibition of protein translation, mitochondrial dysfunction, and behavioral abnormalities in animal models. While relevant to disease pathogenesis, it is not considered a classical drug target, but is notable for its role in the molecular etiology of psychiatric illness in the context of chromosomal rearrangement
- Other names
- BoymawBOYMAWDISC1FP1
02
Mechanism of action
The pathogenesis is attributed to loss of normal gene function and toxic gain-of-function effects of fusion proteins, particularly inhibition of protein translation and mitochondrial abnormality
03
Biological functions
Contributes to inhibition of intracellular oxidoreductase activities, rRNA synthesis, and protein translation when present in fusion form (DISC1-Boymaw)May regulate mitochondrial function and protein stability in its fusion protein context
04
Disease associations
Neuropsychiatric disorders, especially schizophrenia, major depression, and bipolar disorder—all linked to the chromosomal translocation and fusion eventsErythropoiesis abnormalities (as seen in mouse models), possibly contributing to depression and anemia
05
Safety considerations
Not applicable in terms of drug therapy, but gene disruption or fusion can lead to severe neuropsychiatric and hematologic symptoms
06
Biomarkers
Increased red cell distribution width (RDW) has been observed in animal models and found correlated with depression in humans, proposed as a biomarker for erythropoietic and neuropsychiatric dysfunction
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