Disco-interacting protein 2 homolog A (DIP2A)

Disco-interacting protein 2 homolog A (DIP2A) is a broadly expressed intracellular and membrane-associated protein encoded by the DIP2A gene. Bioinformatic and experimental data suggest DIP2A is a Type I receptor-like molecule with DMAP, CaiC, and AMP-binding domains, possibly enabling it to act in ligand-receptor interactions or as a metabolic enzyme. DIP2A is prominently expressed in the nervous system—including neurons in the cortex, hippocampus, and cerebellum—where it is implicated in dendritic spine formation, synaptic transmission, and protein acetylation (notably cortactin acetylation, essential for neural connectivity and autism-relevant phenotypes)[2][3]. It acts as a putative receptor for Follistatin-like 1 (FSTL1), mediating protective effects in cardiomyocytes and endothelial cells, and plays additional roles in the reproductive, vascular, renal, and respiratory systems[1][3]. Genetic disruption of DIP2A in mice leads to neurodevelopmental abnormalities, including autism-like behaviors, altered spine morphology, and synaptic defects[2]. DIP2A is considered a candidate gene for autism spectrum disorder and is under investigation for its physiological and pathological roles. Established roles as a clinical drug target, biomarkers, or significant safety concerns are not yet supported in the primary literature.

Other names

DIP2AC21orf106DIP2KIAA0184DIP2 homolog Adisco-interacting protein 2ADIP2 disco-interacting protein 2 homolog A

No details available about direct mechanisms of pharmacological action; main functional role is as a putative receptor for FSTL1 and in protein acetylation in neurons