Discoidin, CUB and LCCL domain-containing protein 2 circular RNA (circDCBLD2)

Discoidin, CUB and LCCL domain-containing protein 2 circular RNA (circDCBLD2), also known as hsa_circ_0000203, is a non-coding RNA transcript produced by the back-splicing of exons from the DCBLD2 gene (UniProt Q96PD2). This circular RNA is characterized by its high stability and resistance to exonucleases, making it a persistent regulator within the cellular environment (PubMed: 32498355). In the context of oncology, circDCBLD2 is frequently overexpressed and functions as an oncogenic driver in various solid tumors, including colorectal, gastric, and lung cancers. Its primary mechanism of action involves acting as a 'miRNA sponge,' where it sequesters microRNAs such as miR-345-5p and miR-145-5p, thereby relieving the translational repression of their target oncogenes (PubMed: 33414444). This activity promotes key malignant phenotypes, such as increased cell proliferation, migration, and invasion. While no clinical drugs currently target circDCBLD2, it is a promising candidate for RNA-targeted therapies and serves as a potential biomarker for cancer diagnosis and prognosis.

Other names

cDCBLD2hsa_circ_0000203circular RNA DCBLD2ESDN circular RNACLCP1 circular RNA

Acts as a competitive endogenous RNA (ceRNA) by sponging microRNAs, which prevents the degradation of target mRNAs and promotes oncogenic signaling pathways (PubMed: 32498355).