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Target intelligence / Profile preview
Discoidin domain-containing receptor 2 (DDR2)
- Target
- DDR2
- Molecular classification
- Receptor, Receptor Tyrosine Kinase (RTK)
01
Overview
Discoidin domain-containing receptor 2 (DDR2) is a receptor tyrosine kinase that binds to fibrillar collagens. Upon collagen binding, DDR2 undergoes autophosphorylation and initiates downstream signaling cascades that regulate cell differentiation, proliferation, migration, survival, and remodeling of the extracellular matrix. DDR2 plays key roles in cell-matrix interactions and tissue development. Dysregulation or mutation of DDR2 is linked to fibrosis and cancer progression.
- Other names
- CD167bneurotrophic tyrosine kinase receptor-related 3tyrosine-protein kinase TYRO10NTRKR3TKT
02
Mechanism of action
Inhibition of DDR2 tyrosine kinase activity or disruption of collagen binding.
03
Biological functions
Cell-matrix interactionsCell differentiationCell proliferationCell migrationCell survivalExtracellular matrix (ECM) remodelingSignal transduction
04
Disease associations
FibrosisCancer
05
Safety considerations
Potential for off-target effects due to kinase inhibitor promiscuity.Disruption of normal ECM remodeling.
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