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Target intelligence / Profile preview
Discoidin domain-containing receptor protein tyrosine kinase 2 (DDR2)
- Target
- DDR2
- Molecular classification
- Receptor, Enzyme, Receptor tyrosine kinase
01
Overview
DDR2 is a receptor tyrosine kinase activated by fibrillar collagens. It plays a role in cell differentiation, ECM remodeling, migration, proliferation, and survival. Dysregulation of DDR2 is implicated in fibrosis and cancer.
- Other names
- Discoidin domain-containing receptor 2CD167bTyrosine-protein kinase TYRO10Neurotrophic tyrosine kinase, receptor-related 3Receptor protein-tyrosine kinase TKT
02
Mechanism of action
Tyrosine kinase inhibition (for potential inhibitors)
03
Biological functions
Cell differentiationRemodeling of the extracellular matrixCell migrationProliferationSurvivalCell adhesionSignal transduction
04
Disease associations
FibrosisCancer
05
Safety considerations
Potential for off-target effects due to kinase inhibitor promiscuityDisruption of normal tissue remodeling processes
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