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Target intelligence / Profile preview
Discoidin domain-containing tyrosine-protein kinase (DDR2)
- Target
- DDR2
- Molecular classification
- Receptor Tyrosine Kinase, Discoidin Domain Receptor
01
Overview
Discoidin domain-containing tyrosine-protein kinase 2 (DDR2) is a receptor tyrosine kinase activated by fibrillar collagens. It plays a crucial role in cell differentiation, proliferation, migration, and extracellular matrix remodeling. DDR2 dysregulation is implicated in fibrosis, cancer progression, and arthritis, making it a promising therapeutic target.
- Other names
- CD167bTyrosine-protein kinase TYRO10Receptor protein-tyrosine kinase TKTNeurotrophic tyrosine kinase, receptor-related 3NTRKR3
02
Mechanism of action
Tyrosine kinase inhibitor; targets DDR2 autophosphorylation.
03
Biological functions
Cell differentiationCell proliferationExtracellular matrix remodelingCell migrationCell adhesionSignal transductionOsteoblast differentiationChondrocyte maturation
04
Disease associations
FibrosisCancerMetastasisArthritis
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