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Discoidin domain receptor 1 (DDR1)

Target: DDR1
Molecular classification: Receptor Tyrosine Kinase

Overview

Discoidin Domain Receptor 1 (DDR1) is a receptor tyrosine kinase (RTK) activated by collagen binding. It regulates cell adhesion, proliferation, differentiation, and migration, and is implicated in cancer, fibrosis, and inflammation. DDR1 modulates multiple intracellular pathways, including RhoA-ROCK signaling. Several small molecule inhibitors originally developed against Abl kinases (imatinib/dasatinib/nilotinib) also inhibit DDR kinases.

Other names: CD167a

Mechanism of action

Inhibition of DDR1 kinase activity

Biological functions

Cell adhesionProliferationDifferentiationMigrationECM remodelingSignal transductionTissue homeostasis

Disease associations

CancerFibrosisInflammationAtherosclerosis

Interacting drugs

Imatinib

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