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Target intelligence / Profile preview
Discoidin Domain Receptor 2 (DDR2)
- Target
- DDR2
- Molecular classification
- Receptor Tyrosine Kinase (RTK), Discoidin domain-containing RTK
01
Overview
Discoidin Domain Receptor 2 (DDR2) is a receptor tyrosine kinase activated by fibrillar collagens (types I, III, X). It plays a crucial role in cell-matrix interactions, influencing cell differentiation, ECM remodeling, cell migration, and proliferation. Dysregulation of DDR2 is implicated in diseases like fibrosis, arthritis, and cancer, making it a potential therapeutic target.
- Other names
- CD167bTyrosine-protein kinase TYRO10Neurotrophic tyrosine kinase, receptor-related 3TYRO10Discoidin domain-containing receptor tyrosine kinase 2
02
Mechanism of action
Inhibition of DDR2 kinase activity to block downstream signaling pathways involved in cell growth, differentiation, survival, migration, and matrix remodeling.
03
Biological functions
Cell proliferationCell migrationCell survivalRegulation of cell differentiationRemodeling of the extracellular matrix
04
Disease associations
FibrosisCancerSkeletal disorders (e.g., spondylo-metaepiphyseal dysplasia)Arthritis/joint disorders
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