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Discoidin Domain Receptor Tyrosine Kinase (None)

Target: None
Molecular classification: Receptor Tyrosine Kinase

Overview

Discoidin domain receptor tyrosine kinases (DDRs) are a unique family of receptor tyrosine kinases (RTKs) that function as non-integrin collagen receptors. Unlike most RTKs, DDRs are not activated by soluble growth factors but instead by binding to collagens. There are two main subtypes in mammals: DDR1 and DDR2. They play key roles in cell adhesion, migration, proliferation, ECM remodeling, tissue homeostasis, and are implicated in cancer and fibrosis.

Mechanism of action

Tyrosine kinase inhibition

Biological functions

Signal transductionCell adhesionCell migrationCell proliferationECM remodelingRegulation of cell polarityTissue morphogenesis/developmental processesDifferentiationMaintain tissue homeostasisSensing ECM/collagen

Disease associations

CancerFibrosis

Interacting drugs

RXC009

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