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Target intelligence / Profile preview
Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1)
- Target
- DDR1
- Molecular classification
- Receptor Tyrosine Kinase (RTK), Transmembrane protein
01
Overview
Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) is a receptor tyrosine kinase activated by collagen binding. It plays key roles in cell adhesion, migration, proliferation, and differentiation, and is implicated in cancer progression and fibrosis. DDR1 is expressed largely in epithelial cells, with overexpression noted in many cancers, making it a potential therapeutic target. Alternative splicing generates several isoforms with varying functional properties.
- Other names
- CD167a
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell adhesionCell migrationCell proliferationCell differentiationImmune modulationECM remodeling
04
Disease associations
CancerFibrosis
05
Safety considerations
Potential for off-target effects due to kinase homologyDevelopment of resistance
06
Biomarkers
DDR1 overexpression in tumor tissues
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