Discs large MAGUK scaffold protein 2 (DLG2)

Discs large MAGUK scaffold protein 2 (DLG2) is a member of the membrane-associated guanylate kinase (MAGUK) family and is encoded by the DLG2 gene. It is predominantly expressed in the central nervous system, localizing to the plasma membrane and vesicles in the brain[2][4]. DLG2 acts as a postsynaptic scaffold protein at excitatory synapses, forming multimeric complexes that cluster receptors, ion channels, and signaling proteins, including NMDA receptors and inward rectifying potassium channels[1][5]. It is essential for synaptic organization, regulation of NMDA receptor signaling, and synaptic stability. Genetic alterations in DLG2 are associated with increased risk of neurological disorders such as autism spectrum disorder and epilepsy but it is not itself a direct therapeutic drug target.

Other names

DLG2Postsynaptic density protein 93 (PSD-93)Channel-associated protein of synapse-110 (chapsyn-110)

No drug acts directly by binding or modulating DLG2. NMDA receptor antagonists may interfere with protein complexes involving DLG2, but the pharmacological mechanism involves receptor blockade rather than DLG2 modification.