Disease-Causing Protein

Disease-causing proteins are proteins that, due to genetic mutations, misfolding, or abnormal structural changes, disrupt normal cellular functions and lead to a wide range of diseases. These proteins can either gain toxic functions or lose their normal biological activity, resulting in cellular dysfunction and disease pathology. Examples include prions, amyloidogenic proteins, oncogenic proteins, and viral oncoproteins. Therapeutic strategies target promoting correct folding, inhibiting aggregation, correcting genetic defects, and disrupting interactions with host factors.

Other names

Pathogenic ProteinMisfolded ProteinOncogenic ProteinToxic Protein

Promoting correct folding/degradation, inhibiting aggregation/toxicity, targeting underlying genetic defects, disrupting interaction with host factors