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Target intelligence / Profile preview
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
- Target
- ADAM10
- Molecular classification
- Metalloprotease, Disintegrin, Membrane protein
01
Overview
ADAM10 is a zinc-dependent metalloprotease involved in the ectodomain shedding of various transmembrane proteins. It plays crucial roles in neural development, immune regulation, and APP processing, making it a potential therapeutic target for neurological disorders, skin diseases, and Alzheimer's disease. However, its broad substrate specificity and potential for developmental defects raise safety concerns.
- Other names
- CDw156CD156c
02
Mechanism of action
Inhibition of metalloprotease activity, modulation of ectodomain shedding
03
Biological functions
Ectodomain sheddingNeural developmentImmune system regulationAmyloid precursor protein (APP) processing
04
Disease associations
Neurological disordersAlzheimer's diseasePsoriasisDevelopmental defects
05
Safety considerations
Potential for developmental defects if inhibited during critical periodsOff-target effects due to broad substrate specificityDysregulation of multiple signaling pathways
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