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Target intelligence / Profile preview
Disintegrin and Metalloproteinase Domain-Containing Protein 17 (ADAM17)
- Target
- ADAM17
- Molecular classification
- Enzyme, Metalloproteinase, Disintegrin
01
Overview
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), also known as tumor necrosis factor-α-converting enzyme (TACE), is a membrane-bound metalloprotease that sheds various cell surface proteins, including cytokines, growth factors, receptors, and adhesion molecules. It plays a crucial role in inflammation, cancer, cardiovascular disease, and neurodegeneration by regulating signaling pathways through the controlled release of these proteins. Regulation occurs at multiple levels, and dysregulation can contribute to several diseases.
- Other names
- TACETumor necrosis factor alpha-converting enzymeCD156bSnake venom-like proteaseEC 3.4.24.86
02
Mechanism of action
Inhibition of ADAM17 activity to prevent shedding of substrates.
03
Biological functions
Proteolytic sheddingCytokine releaseGrowth factor signalingCell-cell interactionsNotch pathway activationInflammationVascular tone regulationNeurogenic regulation
04
Disease associations
CancerInflammationCardiovascular diseaseNeurodegenerative diseaseHypertensionHeart failure
05
Safety considerations
Off-target effects due to broad substrate specificityPotential for disruption of essential physiological processes
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