Disks large-associated protein 1 (DLGAP1)

Disks large-associated protein 1 (DLGAP1) is a major postsynaptic scaffold protein highly enriched in the brain’s synaptosomal fraction and localized at the postsynaptic density (PSD) of glutamatergic neurons. DLGAP1 links core synaptic scaffolds such as the DLG/PSD-95 and SHANK families, facilitating the assembly of protein supercomplexes that organize synaptic signaling and plasticity. Genetic variants in DLGAP1 are associated with schizophrenia, autism spectrum disorder, and obsessive-compulsive disorder, with evidence suggesting that loss of function impairs PSD organization and sociability in animal models. DLGAP1's role is structural and regulatory within the synapse, forming connections between scaffolding proteins but not acting as a receptor or enzyme. No known drugs currently target DLGAP1 directly; rather, its dysfunction contributes to risk of complex brain diseases.

Other names

DLGAP1DAP-1GKAPSAPAP1hGKAPguanylate kinase-associated proteinPSD-95/SAP90-binding protein 1SAP90/PSD-95-associated protein 1DLGAP1ADLGAP1Bdiscs large homolog associated protein 1

Not applicable; DLGAP1 is not a classical drug target, thus no direct mechanism of drug action is described