Disks large-associated protein 5 (DLGAP5)

Disks large-associated protein 5 (DLGAP5), also known as DLG7 or HURP, is a cell cycle-regulated mitotic spindle protein that plays a critical role in organizing the mitotic apparatus and ensuring proper chromosome congression and segregation during cell division[1][2][3]. DLGAP5 stabilizes kinetochore fibers and microtubules near chromosomes, aiding accurate mitosis, and is regulated by phosphorylation via Aurora kinase[2]. Overexpression of DLGAP5 is common in diverse malignancies, promoting cell proliferation, cell cycle progression, and tumorigenicity; its downregulation leads to G2/M arrest and suppressed proliferation and migration. DLGAP5 is frequently upregulated in cancers (lung, liver, breast, ovarian, colorectal, glioma) and serves as a prognostic indicator and potential biomarker[1][2][3]. The mechanism of action for drugs targeting DLGAP5 involves cell cycle inhibition and induction of apoptosis, often via kinase pathways. There are ongoing efforts to develop DLGAP5 inhibitors based on network pharmacology, with some evidence that existing drugs such as sorafenib and taxol interact with the pathway[3].

Other names

Disks large-associated protein 5DLGAP5Disks large-associated protein DLG7DLG7HURPHepatoma up-regulated proteinDiscs large homolog 7DAP-5KIAA0008

Kinase inhibitors (e.g., sorafenib sensitizes cells to taxol via DLGAP5 downregulation)[3]. DLGAP5 knockdown or inhibition leads to cell cycle arrest (G2/M phase), impaired cell proliferation and migration, and induces apoptosis[3][1][2]