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Target intelligence / Profile preview
Disks Large Homolog 4 (None)
- Target
- None
- Molecular classification
- MAGUK protein, Scaffolding protein
01
Overview
Disks large homolog 4 (DLG4), also known as postsynaptic density protein 95 (PSD-95) or synapse-associated protein 90 (SAP-90), is a key postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for clustering crucial synaptic proteins at the postsynaptic density of neurons. Alterations in DLG4 expression or function have been linked to neurological disorders involving impaired synapse formation or plasticity.
- Other names
- PSD-95SAP-90
02
Mechanism of action
DLG4 antagonists (under development)
03
Biological functions
Postsynaptic scaffoldingClustering of neurotransmitter receptorsSynaptogenesisSynaptic plasticitySignal transductionRegulation of excitatory neurotransmission
04
Disease associations
Intellectual disability syndromesAutism spectrum disorderNeurodevelopmental disordersNeuropsychiatric disorders
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