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Target intelligence / Profile preview
Divalent Metal Transporter 1 (DMT1)
- Target
- DMT1
- Molecular classification
- Transporter, Nramp family
01
Overview
Divalent Metal Transporter 1 (DMT1), also known as NRAMP2, DCT1, or SLC11A2, is a proton-coupled symporter responsible for the transport of divalent metal ions across cellular membranes. Its primary function is the uptake of ferrous iron (Fe²⁺), but it can also transport other metals like manganese, cadmium, cobalt, nickel, vanadyl, and lead. DMT1 plays a crucial role in intestinal iron absorption and cellular iron acquisition, particularly in erythroid precursor cells. Expression is regulated by systemic iron levels, and mutations can cause severe anemia. It is explored as a therapeutic target for diseases associated with pathological iron overload.
- Other names
- NRAMP2DCT1SLC11A2
02
Mechanism of action
Pharmacological inhibition of DMT1
03
Biological functions
Intestinal iron absorptionCellular iron acquisitionDivalent metal ion transport
04
Disease associations
Microcytic-hypochromic anemiaHereditary hemochromatosisMetal toxicity (e.g., manganese, cadmium)Iron overload disorders
05
Safety considerations
Potential disruption of systemic iron homeostasisOff-target effects on other divalent metal transport
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