Divergent protein kinase domain 2B (DIPK2B)

Divergent protein kinase domain 2B (DIPK2B) is a poorly characterized protein encoded by the DIPK2B gene (also known as CXorf36) located on the X chromosome[4][6][10]. It is a member of the FAM69 family and contains a divergent, atypical protein kinase domain, with possible EF-hand calcium-binding motifs[3][8]. The protein's exact molecular function in humans is not known, though it is predicted to possess kinase activity and features several sites for post-translational modification, including phosphorylation and one predicted glycosylation site[1][3][6]. DIPK2B is expressed at low to moderate levels in a wide range of adult and fetal tissues, with higher expression in trigeminal ganglia, ovary, and brain regions[6][7]. No experimental data exist for endogenous interacting proteins, substrates, or upstream regulators. While DIPK2B has been linked by association studies to autism spectrum disorder and muscular dystrophy in rare cases, it is not currently considered a validated therapeutic target, and there are no known drugs, biomarkers, or clinical trials focused on DIPK2B[5][13].

Other names

CXorf36DIA1RFLJ14103UNQ1862/PRO37434930578C19RikEPQL1862PRO3743bA435K1.1UPF0672 protein CXorf36deleted in autism-1 related proteinhCG1981635

not established (no approved or candidate drugs documented)