Diverse skin proteins

The term "diverse skin proteins" refers to the many proteins expressed in human skin, including structural proteins such as keratins, enzymes, immune regulatory proteins, cell adhesion molecules, and others. These proteins collectively provide key skin functions, including barrier formation, mechanical strength, immune defense, pigment production, and wound healing. The skin proteome comprises over 6000 identified proteins, many of which are shared across other tissues, while some exhibit skin-restricted or skin-enriched expression patterns. Notable examples include keratin intermediate filament proteins, filaggrin, trichohyalin, S100-family proteins, and others. Because of this diversity and the lack of specificity, “diverse skin proteins” does not identify a single therapeutic or diagnostic target, but rather represents a complex network of proteins crucial for skin integrity, health, and disease[3][4][5][8].