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DLGAP1 antisense RNA 2 (DLGAP1-AS2)
- Target
- DLGAP1-AS2
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
DLGAP1 antisense RNA 2 (DLGAP1-AS2) is a long non-coding RNA located on chromosome 18, transcribed from the opposite strand of the DLGAP1 gene. It does not encode a protein but regulates the expression of other genes, such as up-regulating YAP1 in glioma, and has been shown to promote tumorigenesis and metastasis in cancers such as colorectal cancer. It has been associated as a biomarker with hepatocellular carcinoma and is linked to glioma susceptibility[1][5][6]. There is no evidence that it functions as a traditional druggable target (such as an enzyme, receptor, or ion channel), and there are currently no known drugs that directly target DLGAP1-AS2.
- Other names
- MGC11082GC18P003603GC18P003604GC18P003607GC18P003610GC18P003616GC18P003622GC18P003632GC18P003644GC18P003713GC18P003729GC18P003749
02
Biological functions
Regulation of gene expressionPromotion of tumorigenesis and metastasis (notably in colorectal cancer)Modulation of glioma development (via up-regulation of YAP1 expression)
03
Disease associations
CancerHepatocellular carcinoma biomarkerGlioma susceptibilityColorectal cancer
04
Biomarkers
Biomarker of hepatocellular carcinoma
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