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DMXL1 divergent transcript (DMXL1-DT)

Target
DMXL1-DT
Molecular classification
Long non-coding RNA (lncRNA)
01

Overview

DMXL1 divergent transcript (DMXL1-DT) is a long non-coding RNA (lncRNA) gene, defined as a divergent transcript due to its orientation and location within 300–500 nucleotides of the protein-coding DMXL1 gene on chromosome 5. Divergent transcripts are a type of lncRNA, typically not translated into protein, and often participate in regulatory functions, usually for the expression of nearby genes[2][4][5]. There is currently no evidence that DMXL1-DT encodes a protein or is itself a therapeutic target, receptor, or druggable entity. All known disease and functional associations pertain to the protein-coding DMXL1 gene, not to DMXL1-DT. The DMXL1 divergent transcript (DMXL1-DT) is not a therapeutic target, nor is it a receptor, enzyme, transporter, or similar protein entity. Information on DMXL1-DT is limited, and most research and disease associations refer to DMXL1, a protein-coding gene. The entry "DMXL1 divergent transcript" may be incorrect as a target for drug discovery or pharmacology purposes[2][5].

Other names
DMXL1 divergent transcriptDMXL1-DT
02

Biological functions

unknown; general function for divergent lncRNAs may include regulation of proximal gene expression, but nothing target- or function-specific is established for DMXL1-DT[5].
03

Disease associations

none established; no evidence currently links DMXL1-DT itself to disease, in contrast to the protein-coding DMXL1 gene which has associations in cancer[1].

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