DNA氧化损伤保护 (Protection against DNA oxidative damage)

Protection against DNA oxidative damage refers to the diverse cellular mechanisms that preserve genome integrity from harm caused by reactive oxygen species (ROS). These mechanisms include antioxidant defenses (e.g., catalase, superoxide dismutase, peroxiredoxins, glutathione pathways) as well as specific DNA repair processes, most notably base excision repair, involving enzymes such as OGG1, FPG/MutM, and XPC complexes. The failure of these systems increases the risk of mutations and is implicated in a wide range of diseases. There is no single canonical protein, gene, or receptor for this function; rather, it encompasses networks of molecules and pathways cooperating to protect nuclear and mitochondrial DNA from oxidative attack. This process is essential for genome stability, normal cell function, and the prevention of diseases caused by accumulation of genetic damage.

Other names

Protection from DNA oxidative damageDNA oxidative damage defenseAntioxidant DNA protectionOxidative DNA repair capacity

Reduction of reactive oxygen species (ROS); Enhancement of DNA repair enzyme activity; Modulation of cellular antioxidant systems