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Target intelligence / Profile preview
DNA (cytosine-5)-methyltransferase 3 alpha (DNMT3A)
- Target
- DNMT3A
- Molecular classification
- Enzyme, DNA methyltransferase
01
Overview
DNMT3A is an essential de novo DNA cytosine-methylating enzyme involved broadly across mammalian tissues—especially critical during embryonic development—for setting up stable epigenetic marks that regulate gene expression programs fundamental to health and disease states including cancer predisposition syndromes.
- Other names
- DNA methyltransferase 3A
02
Mechanism of action
Catalyzes the transfer of methyl groups to cytosine residues in DNA at CpG dinucleotides, leading to gene silencing or altered gene expression.
03
Biological functions
De novo DNA methylationEpigenetic regulationTranscriptional repressionStem cell differentiationDevelopmental patterningGenome stability
04
Disease associations
CancerAcute Myeloid Leukemia (AML)Clonal HematopoiesisDNMT3A Overgrowth SyndromeChemoresistance
05
Safety considerations
Potential for off-target effects with DNMT inhibitorsComplex and context-dependent effects of DNMT modulation on gene expression
06
Interacting drugs
DNMT inhibitors (unspecified)
07
Biomarkers
DNMT3A mutations (prognostic/diagnostic in AML and clonal hematopoiesis)DNMT3A expression levels (predictive of chemoresistance)
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