DNA (primary target of platinum agents via adduct formation)

Platinum-based chemotherapeutic agents exert their antitumor effects primarily through the formation of covalent adducts with DNA, causing intra- and interstrand crosslinks that block DNA replication and transcription. This indirect enzyme inhibition results from physical and chemical distortion of the DNA template, which impedes the function of replication and transcription machinery, ultimately leading to cell cycle arrest and apoptosis in cancer cells. These drugs are widely used in the treatment of various solid tumors but are limited by resistance mechanisms and notable toxicities[2][3][5][6].

Other names

Platinum–DNA adductsplatinum-induced DNA damageplatinum crosslinkscisplatin–DNA modification

Formation of platinum–DNA adducts that block DNA replication and transcription machinery; Induction of DNA crosslinks leading to cell cycle arrest and apoptosis; Recruitment/hijacking of transcription factors to damaged DNA.