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Target intelligence / Profile preview
DNA-binding protein Ikaros (IKZF1)
- Target
- IKZF1
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
DNA-binding protein Ikaros (IKZF1) is a transcription factor crucial for lymphocyte development and differentiation. It regulates gene expression through direct DNA binding, dimerization, and chromatin remodeling. IKZF1 acts as a tumor suppressor in B-cell acute lymphoblastic leukemia (B-ALL), with deletions or mutations frequently observed in this disease. Polymorphisms near IKZF1 are associated with both leukemia susceptibility and protection from type 1 diabetes.
- Other names
- Ikaros family zinc finger protein 1Ikaros
02
Mechanism of action
Direct DNA Binding, Dimerization, Chromatin Modification, Transcriptional Activation, Transcriptional Repression
03
Biological functions
Lymphocyte developmentLymphocyte differentiationTranscription regulationChromatin remodelingRegulation of gene expression
04
Disease associations
B-cell acute lymphoblastic leukemia (B-ALL)AutoimmunityCancerImmune disorders
05
Safety considerations
Tumor suppressor loss can lead to cancerAberrant function linked to autoimmunity
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