DNA cross-link repair 1A protein (DCLRE1A)

DNA cross-link repair 1A protein (DCLRE1A, also known as SNM1A) is a highly conserved 5′–3′ exonuclease that plays a critical role in the repair of DNA interstrand cross-links (ICLs), structures that physically block DNA replication and transcription. DCLRE1A works with other DNA repair enzymes, particularly the XPF–ERCC1 complex, to unhook and process cross-linked DNA and is integral to maintaining genomic stability during cell division. Loss or reduction of DCLRE1A activity compromises genome integrity, sensitizes cells to DNA-damaging agents (such as cisplatin and mitomycin C), and has been implicated in rare hereditary diseases and cancer predisposition. Alternative splicing produces multiple transcript variants; DCLRE1A is a target for potential chemotherapeutic sensitization strategies and is also studied as a biomarker in DNA repair research.

Other names

SNM1ASNM1PSO2KIAA0086hSNM1AhSNM1DNA-crosslink repair gene SNM1Beta-lactamase DCLRE1ASNM1 homolog APSO2 homolog (S. cerevisiae)

Sensitization to DNA cross-linking chemotherapeutics by inhibiting DNA repair. Potential for increased cytotoxicity in combination with DNA-damaging agents (e.g., platinum compounds).