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Target intelligence / Profile preview
DNA Cross-Linking Agent
- Molecular classification
- Chemical Entity, Chemotherapeutic Agent
01
Overview
A DNA cross-linking agent is a substance that forms covalent bonds within or between strands of DNA, blocking essential cellular processes such as DNA synthesis, replication, and transcription. These agents are primarily used in cancer therapy to induce apoptosis in rapidly dividing cells by causing irreparable DNA damage. Examples include cisplatin, nitrogen mustards, carmustine, mitomycin C, and psoralen.
- Other names
- DNA CrosslinkerCrosslinking Agent
02
Mechanism of action
Formation of covalent bonds within or between DNA strands, leading to inhibition of replication and transcription, and ultimately cell death.
03
Biological functions
DNA DamageCell cycle arrestApoptosisInhibition of DNA replicationInhibition of transcription
04
Disease associations
Cancer
05
Safety considerations
MyelosuppressionSecondary malignanciesDrug resistanceOff-target toxicity
06
Interacting drugs
Cisplatin
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