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Target intelligence / Profile preview
DNA Crosslinking (Platinum-DNA Adducts) (Pt-DNA Adducts)
- Target
- Pt-DNA Adducts
- Molecular classification
- DNA Adduct, Genomic Instability, Other
01
Overview
DNA crosslinking by platinum-based compounds is a critical mechanism underlying the cytotoxic effects of these widely used anticancer drugs. Platinum-DNA adducts form when platinum compounds covalently bind to DNA bases, primarily at the N7 position of guanine and adenine residues. These lesions disrupt essential cellular processes such as replication and transcription, ultimately triggering cell cycle arrest and apoptosis if not repaired.
- Other names
- Platinum-DNA AdductsCisplatin-DNA AdductsDNA Interstrand Crosslinks (ICLs)DNA Intrastrand CrosslinksPlatinum-induced DNA Damage
02
Mechanism of action
Covalent binding to DNA bases, primarily guanine and adenine, forming intrastrand and interstrand crosslinks, disrupting replication and transcription.
03
Biological functions
DNA Replication InhibitionTranscription InhibitionCell Cycle ArrestApoptosisDNA Repair Inhibition
04
Disease associations
Cancer
05
Safety considerations
Drug resistanceOff-target DNA damageMyelosuppressionNephrotoxicityNeurotoxicityOtotoxicity
06
Interacting drugs
Cisplatin
2 more in the full profile.
07
Biomarkers
Pt-DNA adduct levels (measured by AAS, MS, immunoassays)Expression levels of DNA repair proteins (e.g., ERCC1, BRCA1)Fanconi anemia pathway gene mutations
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