DNA Crosslinking via Oxaliplatin

DNA crosslinking via oxaliplatin refers to the formation of covalent bonds between DNA strands or within a single strand, induced by the platinum-based chemotherapeutic agent oxaliplatin. This process disrupts essential cellular functions such as DNA replication and transcription, ultimately leading to cell death. Oxaliplatin primarily induces intrastrand crosslinks, especially between adjacent guanine bases, but also forms interstrand crosslinks and adducts. The platinum atom in oxaliplatin binds mainly at the N7 position of guanine residues. These adducts bend the double helix, inhibiting replication and transcription. Nucleotide excision repair is primarily responsible for removing oxaliplatin-induced lesions. The cytotoxic effect resulting from this target mechanism underpins the clinical use of oxaliplatin against cancers.

Other names

Oxaliplatin-induced DNA AdductsOxaliplatin-DNA CrosslinksDNA damage induced by oxaliplatin

Formation of DNA intra- and inter-strand crosslinks, primarily at guanine residues, leading to inhibition of DNA replication and transcription and subsequent cell death.